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This is a case for '' size doesn't matter." A well placed .22LR HP in the head & heart will stop anyone.The art of SD is about out smarting an opponent.
I carry a 380 auto as my personal SD weapon because of it's compact size & weight.I keep within reach a Browning Buck Mark .22LR loaded with HP rounds.
1 in the chamber & 10 in the clip.If I can't stop an intruder with the .22LR,I need to hire a guard...
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really what about the Reagan assassination attempt? how many people got shot with a 22lr and didnt die. i have seen many gunshots over the years in my job and the only 22lr deaths that were even close to immediate were in the mouth self inflicted. not long ago i picked up a guy shot in the chest from 7 feet away with a 9mm fmj that hit a rib on his side and followed the rib stopping just under his pectoral muscle. SIZE DOES MATTER. you may trust your life to a 380 but i will stick to somthing bigger.