This is a case for '' size doesn't matter." A well placed .22LR HP in the head & heart will stop anyone.The art of SD is about out smarting an opponent.
I carry a 380 auto as my personal SD weapon because of it's compact size & weight.I keep within reach a Browning Buck Mark .22LR loaded with HP rounds.
1 in the chamber & 10 in the clip.If I can't stop an intruder with the .22LR,I need to hire a guard...