.243 Winchester, 6mm Remington, 25-06 I believe are very good cartridges and the ammo is decent priced. Check out the ballistic tables and you will see for yourself. You will find that the heavier bullets of these cartridges have higher ballistic coefficients and they may not start out with the speed of the 22-250, they come close and the extra weight bullet gives you the extra power you are after.
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