A friend has a modest (4200 sq ft) house in Missouri on 200+ acres.....The response time to his wife's call of "prowlers" around their house had the deputies arriving 49 minutes after the call was made.....
I live in a suburb, but I've often wondered what I would do differently if if I lived on a farm miles from the nearest municipality.
When I was young I used to visit relatives on farms, but there were no meth producers around and I don't remember any difficulties. One uncle kept a Model 1911 under his pillow, and I don't remember whether the other one had anything at hand. Looking back, I'm really amazed that I didn't see a shotgun.
There remains the question of what to do. I do think there may well be a case to be made for a different approach when you are out in the country and really on your own due to the long police response time.
Having said that, I still believe that in town, the only wise thing to do is to follow Keltyke's advice posted at 11:46 AM.