Over the years I've learned, and trained extensively, with both the Weaver and the Modern Isosceles (elbows relaxed and wrists locked -- which I find gives me better recoil management). I now seem to be able to use either with pretty much equal facility. I also find that my point of impact is the same with either.
A few years ago, I decided to test whether or not my POI was actually the same with either stance. This was the result --