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.5 grains difference in a rifle case is no big deal (so long as that .5 doesn't take you over the max you've determined to be safe in your gun of choice)... it can be an issue in small capacity pistol cases, but I've found that most fine powder used in them don't vary by more than .1 or .2 when dropped out of your average rotor-style measure. I just make sure that even it it drop .2 more on occasion that it doesn't take me over my self-established max (often under the book max).
Snuffy's ideas to smooth out your measure operation will help, too... my Hornady measure needed all of those tips, and a thorough degreasing, before it'd behave. Now it's like the rock of gibraltar.
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