Hi Bianchi,
Just tightening the screw may be enough, but some people ground the end down so they could turn the screw in flush and still have a light pull. A new screw may be needed.
You'll probably hit me for this one, but are you sure you are using pistol primers,not rifle primers?
Jim
P.S. I, and everyone else, thought you mean misfires, not hangfires (delay between hammer fall and firing). If you really mean hangfires, look to the primers, as this is usually due to very old or mistreated primers.
Jim
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