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.22s don`t have much stopping power. Simple fix, shoot him more times! BUT, what is safer for you and bystanders: 10 shots of 22 or 1 shot of buckshot?
Not to mention the risk to you because of the time it takes to shoot 10 times.
Same argument for almost all handgun ammo: shoot him till he falls down, or shoot him till you run out of ammo and then pistol whip him until one of you wins the fight. Or just go get shotgun with some buck.
Incidently, i have a very dear friend who I recently set up with a Ruger single six 22 for HD. Why? Because after much experimentation it is the only gun she is strong enough to cock and shoot. That`s pretty much the only reason for picking a 22 for HD. I would have preferred a 410 single shot with buck, but she coundn`t handle it.
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