I believe Hodgdon bought or took over IMR's powder line, and, although they claim to continue the line, one wonders if that makes sense over time. Since IMR 4350 and H-4350 are so close (but not the same) my guess would be we'll see H4350 remain and IMR 4350 disappear over time. So I would concentrate on H4350. However, my experience has been there is very little difference between H4350 and H414, so I use H414 exclusively in my .270 and .270 WSM because it meters better in the powder measure.
I have used RE-19, -22 and -25 in various caliber workups but have never found any that beat the Hodgdon line.
I have a Savage .270 WSM and my problem is not so much finding a powder, but finding a bullet that it likes. H414 in my Win M70 .270 gives me 1.0" groups at 200 yards with a 130gr Hornady SST
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