As I said in an above post, handgun hunting has definitely challenged my deer hunting. Another poster said archery bear. I did that once, too, after killing a few black bears with the rifle. I got one with the bow and it was definitely a high point of my hunting career and the most adrenaline I've ever experienced.
This past weekend's challenge, handgun squirrels. I don't recommend this if you want to make a lot of squirrel stew. I love squirrel hunting, but doing it with a revolver adds a whole new dimension. Lots of shots per squirrel taken, so far: