Being a lefty and wanting to switch from revolvers to a semi-auto it wasn't easy finding one I liked. I settled on the Glock. Which I carried chambered but like my revolver made sure nothing but my finger got in the trigger guard. I never considered carrying with an empty chamber becasue I have kids and if I ever needed my weapon adding an extra step seemed foolish and dangerous.
Today watching this video of a dog attacking a 4 year old I couldn't/can't see myself letting go of my child to chamber a round...
http://www.cnn.com/video/?hpt=hp_t2#...ed-by-dog.wabc