I've killed a fair number of deer with 150-grain: Rem. Bronze Points, Sierra and Hornady flat-base Spitzer, and Sierra SPBT. They all seemed equally effective on whitetail out to 450 yards.
The Sierra 150-grain SPBT didn't exit the two mule deer I used them on; one heart/lung cross-body shot, one neck shot.
I've used the Sierra 165-grain HPBT on whitetail; devastating.
I've not used the Sierra 180-grain SPBT on game, yet. I do know it makes a noticeably greater impact-damage on a 1" steel plate at 500 yards than either the 150- or 165-grain bullets.
26" barrel on my '06.
Since you're apparently not hand-loading, I'd go with the Federal HighEnergy in 165-grain for mulies. I get as good a group with them as with my handloads. (Wuz hoping to use one on a mulie this last season, but the doggoned deer didn't cooperate.)
Hope all this BS helps,
Art
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