Sure, with the slugs you will have some lead buildup and with the birdshot there will be some plastic.
For the plastic use some brake cleaner. Take the barrel outside or your wife will hang you, and be careful of any painted surfaces. Shoot the barrel out the the brake cleaner.
For the lead use a bronze brush with some lead solvent, or a tight jag and patches with lead solvent.
Personally I wipe the bore down with oil to prevent rust between outings and only deep clean bores every 3-5000 rounds. The plastic will begin to peel itself out of the bore keeping the buildup from growing. If you shoot a lot (over 500 rounds or so) of birdshot shoot the barrel out with brake cleaner to get rid of the plastic before shooting slugs.
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