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Interesting I have a good friend and his wife who have the same desire and I cannot talk them out of it even to a 22 Mag, or 32 or 380.
Plenty of folks have been killed with a 22, the problem is by the time they died if they were attacking you, you would probably be killed before they died.
I too have heard CCI is the best and I have shot plenty of small game with a 22 mostly head shots but if I wanted to penetrate a man's skull or ribcage with a 22 I would probably use solids.
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