I have shot one deer with the 22-250 at about 150 Yds. One shot in the lungs droped it where it stood. I have some 60 Gr bullets loaded in a 220 Swift that I my use on deer this year. With 60 Gr Nosler Partition bullets you should be able to get 1,000 ft/lb energy out to about 175 yds. with your 22-250. A 243 Win would be better round but since you have the 22-250 get only bullets that are made for shooting big game and keep the shots under 200 Yds. and put the bullet into the heart lung area.
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