The only time I can see where empty hand would be better than knife in hand is where your simply wanting to restrain or apply a force compliance technique.
You can use a knife to deliver non lethal attacks, using hilt/spine/side of blade, but still possible to end up cutting someone you didn't intend to cut.
From what I understand a sword would probably be better for non lethal [er non cutting/stabbing] attacks than a knife because it has more mass and with it's reach/length can be driven to higher speeds [at the tip].
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