A Nebraska gunsmith/varmint hunter, Jerry Gebby, was the person most responsible for the success of the "Varminter", as he called the .22-250 wildcat back in the 1930s.
It and the .220 Swift are the top of the line in hotshot .22s.
Unless your shooting is rather infrequent, I urge you to also consider reloading. You can load down from maximum, for longer barrel life; you can find some particular combination of powder charge and bullet which maximizes your accuracy.
My uncle had a Gebby-barrelled rig back in the early 1950s. It was indeed rough on jackrabbits. I had a Sako .22-250 for a while; it was equal in performance to my Swift for jackrabbits and feral cats out to 300 yards and more. Any really-hot .22 will serve for coyotes, as well.
They can, with heavy bullets, be used for deer hunting, but I consider that to be marginal for anybody but experienced, skilled hunter/shooter types.
Regards,
Art
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