If you are trying to save the skins the 243 and 270 may be a little hard on them.
If you are a good shot with your 22 and your shots will be between the 35 to 75 yard distance you mentioned I would most likely go with that.
If I was using a 22 I would try for head shots and pratice with the 22 making some quick follow up shots.
Best Regards
Bob Hunter
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