Oregongundude, .40 S&W can definitely kill a bear, and so can a .22, but there's no way in hell I would use a .22 for bear defense. Especially since they are considered back-up nose guns for human defense. Using a .40 on an animal that can run over 30 miles per hour, has huge claws and teeth, has heavy bones, and extremely strong is very unwise and potentially deadly for the person behind the gun.
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