Since the OP is talking about SA with a 6" barrel I'm assuming he's thinking about a revolver.
If so, the regular .22 has many options ranging from the CB Short all the way to the formidable 40gr Long Rifle Mini-Mag, and beyond for the brave of heart. IOW, more variety and easier to find something that will work with the gun.
With the .22 mag you're pretty much "stuck" with .22 mag ammo.
The two-cylinder conversion guns would be a good option.
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