BigBore,,,,,you should get this book and read it before you buy. It will help you a LOT!!
http://www.amazon.com/Big-Bore-Revol.../dp/1440228566
I went with the Taurus Raging Bull 454 Casull. Its more than enough gun for a deer. I bought mine for hogs,,,and buddy It will put them down!! With regular factory loads I can shoot the gun with one hand. The ported barrel helps a lot!
But to answer your question,,Im pretty sure you cant shoot a 460 round in a gun rated for 454. The 460 shell is longer.