I think your problem may be the jacketed bullets. Speer has a warning about them.
Quoting from the Speer manual.
Quote:
Jacketed bullets create more resistance than lead bullets and can actually stick in the bore with charges that are too light.... To avoid these problems, we are showing jacketed bullet data for only the 110 and 125 grain bullets. Heavier bullets may not attain sufficient velocity to reliably overcome friction. Note that these loads are marked "DNR" meaning "do not reduce". Reductions of loads below the levels shown can result in a bullet-in-bore condition in revolvers with excessive barrel/cylinder gaps.
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For the 125 grain jacketed bullet they are showing a charge of 5.7 grains of Unique and 4.4 grains of Tite-Group.
You're below their minimum for Unique, and right at the limit for Tite-Group.
I would suggest you just switch to cast bullets.