I've always used carbide dies ...and I've always used spray lube on the cases...and no, its no big deal.
I will typically run about 2,000 - 3,000 rounds at a time in one caliber....and when I change calibers, I always take the dies apart and clean them / but a pipe cleaner works real well on the resizing - depriming die if you don't want to take it apart.../ and there is always a little bit of crud up in there...but nothing that would prevent the die from working properly if I didn't clean it for 30,000 rounds probably...
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