What happens to a human being when they are hit with a bullet 9 times out of 10? Do they continue moving towards you? My bet is they will dive for cover or attempt evasive action if they are not killed. How many targets will continue towards you at a high rate of speed if hit with 2-3 bullets? Even if the hits were in the legs or arms, what are the chances they will continue?
Some may point out examples like the Miami shooting, but Im willing to bet those are anomalies caused by a highly motivated and well trained aggressor under unusual circumstances.
A few bullets of any caliber will do some damage and I can bet the target isnt going to be moving quite as fast once hit with a few bullets of any caliber.
However, I will take the .45 for home defense