Jimmy a .38 revolver from one of the well respected gun manufacturers makes a great SD weapon. The 9mm .40 cal. and .45cal. are the most popular SD pistol calibers.
Today the modern semi auto is very reliable. There are a few exceptions but a 9mm Glock, Sig, Rugar, Smith to name a few will all serve you well. I suggest you handle a few down at the gun store and rent the one's that feel best in your hand.
Sig and H&K both make very high quality 9mm's. They come at a premium price however. If money isn't an issue they would be the first two I would look at. Good luck.
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