Any gun you have with you when you need one is way better than the best one you own that is sitting somewhere where you can't get to it.
Having said that, I have a .32 but don't carry it too often, not small enough for when I want to go small. When I really want a small (summer, shorts, bicycle, dogs) gun I go with a M21.
Don't scoff, if you remember RFK took two rimfire rounds to the mellon and was done for. Shot placement is always the key. A .22 in the mellon will do more for you than a .357 flesh wound will.
Before this gets carried away, just go back to the top of the reply