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The advantages of the 6.5mm over the .243" (aka 6mm) is the 6.5mm across the board has higher BC bullets giving them less drift, less drop, and higher retained energy at range. In addition to that it has the typical advantages of a larger caliber in that it makes a larger wound throughout and can use higher bullet weights where the 243 cals effectively max out between 90-100gr (rifling limited) almost all 6.5s will handle 160gr bullets should you need such a javelin.
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