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Oh, I don't know. At 300 yard range, a 45 gr Hornady bullet that left the muzzle at just over 2700fps would still be going over 1600 fps. That means it's carrying a significant percentage more energy at 300 yards than a standard velocity 22 LR has at the muzzle. I don't think anybody would claim you couldn't kill a even a coyote with a 22 if they were standing right in front of you.
For that range, I would get at least a 12X scope if I were shooting varmints.
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