I cannot believe that, in the 21st century, we still have people recommending ball ammo in a .45. Ball ammo is not a good manstopper, even in .45.
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You need all of the penertrtion that you can get.
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No, you don't. There is such a thing as overpenetration, and it's not desirable.
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The energy spent opening a HP will cause lack of penetration.
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No, it won't. There are a good number of HP rounds that will give excellent penetration without overpenetrating and failing to transfer much of the bullet's kinetic energy, as ball ammo will do.