No experience with the 357, I have taken a dozen or so deer with .223 using neck shots, none has taken a step. Gun and shooter have to be very accurate for that or I suppose it could get ugly.
Was watching a Guns and Ammo the other day and saw that one of the manufacturers, can't remember which, has come out with an AR for you backwards guys. Might want to look into that since it would give you some options in calibers.