Good morning and congratulations on buying a VERY fine gun for self-defense! :-)
The G17 will require very little break-in time; once they're cleaned and lubed, they're ready to run. Now, despite the fact that it's one of the most unpicky semi-automatic handguns ever made as far as types of ammo that it will feed, you should still run at least 100 failure-free rounds through it before loading it with that ammo for defense.
I like to really challenge my guns: for each type of ammo I test, I shoot it with both hands, with only my strong hand, with with only my weak hand and with a very loose grip on the gun. Any failure or stoppage and I move on to the next type of ammo.
Again, congrats on the gun. It's tough to find ammo lately. Personally, I have never had a single failure in any of my Glocks with Speer Gold Dot ammo. If you can find that, it would be a good place to start.
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"If the sole purpose of handguns is to kill people, then mine are all defective." - Uncle Ted Nugent
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