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I got to think getting shot with a .22 caliber bullet at reasonably close range is going to discombobulate the victim and disengage them from whatever they were doing. Most bad guys are not heroes and they've never been shot. An entirely new and unexpected experience. At this point -- if they survive the first shot (and professional mob hit men are said to use .22) -- their attack has been blunted, at the very least. Their aim is not going to be as good. They may very well be on the floor. Now, if you're talking a grizzly bear or a charging rhino, yeah, I'd want a small cannon. And usually, with .22 ammo you've got plenty more where that came from if the first wasn't persuasive.
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