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That specific ammo will penetrate "significantly". So far, I've not had one stop inside a deer even at ranges over 100 yards or as close as 20 yards(from a 16" Win 94 Trapper). Usually produces about 1" exit hole on ribcage hits even when bone is not hit.
I would say this load would punch through most obstacles and/or 2 or more humans or 1 fairly large bear.
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