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The bigger problem would be leading. If you have a 5.56 suppressor it is likely welded shut to handle the pressure. .22 is a dirty round and will fill a can with lead. You can shoot .22 in a 5.56 can but you risk filling it up with crud. If you want to suppress your .22 conversion you should get a take-apart .22 can so you can clean the crap out of it.
...This is where someone chimes in and says that I am wrong and they shoot .22 in their sealed can all the time...
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"9mm has a very long history of being a pointy little bullet moving quickly" --Sevens
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