I've learned over the years that shot placement and multiple hits on target are more important than caliber or millimeter size. You hit a guy square in the head a couple of times with a .22 long rifle and you're probably going the win the day. If you do 2 to the chest and 1 or 2 to the head, that will probably make you a winner too. I do, however, personally prefer using the larger and heavier bullets when I can, but if I can't, I do multiple shots and go for good shot placement.
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