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One of the most accurate loads i ever tried in 5 inch semi was a 255 grain lrnfp from 45 acp. The target version was around 710 fps using unique and a common cowboy action bullet. The heavier version used a lee molded 255 lrnfp with a rather large meplat grtting apr 850 fps. Not presure tested but likely a hotter load and used a heavier recoil spring.
Where col is used is pistol/barrel leade/chamber cut dependent.
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