I personally wouldn't be taking any head shots in a SD/HD situation except in the situation of "2 to the chest then 1 to the head."
That aside I'd definitely prefer to be shooting the 12ga. than the .22LR. A 12ga loaded with a 2 3/4" #4 shell would be sufficient for taking care of most any two legged varmint that makes their unwanted way into my home. A .22LR may or may not get the job done and for that matter may just end up angering said varmint.
If all you have is a .22lr or all your wife will use is a .22lr then by all means use it. Otherwise its wiser to go with a larger caliber firearm for HD.
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