hoytinak wrote
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I keep the same zero on my 22/45 set at 25yrds (our 8" plates are set at 15,25 and 50) and it does just fine using Federal bulk packs.
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8" PLATES 
Dang, if that's all I was shooting at I wouldn't even HAVE sights, much less worry about adjusting them
The topic is BULLS EYE shooting, not
"8 ring shooting".
Seriously, Hoyt brings up a good point, the ballistics of the .22 cartridge is such that there's not a great deal of rise/fall within the first 50 yards; it's generally between 50 and 100 yards where things start to fall apart, and beyond 100 yards, there's quite a bit of drop.
This chart pretty clearly show that there's only a couple of inches variation between zero and about 70 yards - certainly not enough to warrant fiddling with the sights.
All the best,
Rob