Seems to me that if you were talking about storing a shotgun, AR-15, or similar for home defense in a single gun safe, rack, etc., storing with the muzzle down would allow you to retrieve and position the gun quicker and with just your strong hand, especially if it has a pistol grip. I have always thought this would be the way I would choose for that application. All my long guns are stored in my safe with the muzzle up.
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