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12 ga slugs out of a smooth bore shotgun barrel are probably best at distances 50-75yards or less just because of accuracy issues, which for hunting in the woods may be much more range than you will need. The same for the 20 ga. The .22-250 should work fine.
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You really think the .22-250 would work? Obviously I'd need something in the 55gr+ range, correct?
Both of our 12ga have rifled barrels, so the range is a bit more than 50-75, though I wouldn't go much past that just because it gets hard to see out that far.