Everything I've read about lower-48 black bear indicates that a heavy bullet from a .357 should be plenty.
Mountain lions are comparatively fragile, both physically and psychologically. Not all that hard to kill; not all that hard to scare. A lion that had attacked a couple of kids up in Big Bend National Park, some years back, was killed via a .38 Special. (Dunno how many shots or what ammo. Probably 158-grain RNL, from knowing the shooter.)
Art
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