[amd6547]

That would difficult, if not impossible to answer.
However, the use of the Beretta Model 70 in 22lr as a concealed carry weapon by the Mossad points to the ability of the rimfire to serve as a weapon...and not just as a covert assassination weapon.
The famouse account of the El Al sky marshal defeating a band of armed hijackers with his Beretta 70 22 is legendary...
I don't know what kind of ammo they used back then, but I believe the 22LR ammo we can choose today is even better.