4227 is a VERY slow powder by handgun standards.
I used to load it in .44 Magnum because it was more accurate than with 2400, but I was giving up substantial velocity.
If you are a "clean powder" shooter, the amount of unburnt powder left in the barrel will annoy you.
I also shot some in a .44-40 and it was a good stout load at handbook specifications.
I no longer have the book with the Hank Williams Jr preferences. I recall that he did a lot of loading in cahoots with Mike Venturino, who seems to know his stuff.
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