Glock recommends against the use of lead bullets in their pistols (though the manual is silent in terms of an explicit warning to that effect). According to Glock, at least one other expert in the field and some pressure measurements from a forensic engineer, the polygonal rifling can result in rapid barrel leading which causes dangerously increased pressures.
I know that some people do it and get away with it, and there are ways to much reduce the chances of having an incident, but unless you know them already, you really shouldn't be reloading for Glocks.
Polygonal rifling tends to be more resistant to wear, can offer higher velocities than standard rifling, and is generally easier to clean. The downside is that it's not such a good idea to shoot unjacketed rounds through it.
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