There are much better rounds for over 400 yards than either BUT the 22/250 is the winner of the two in the field. In real life, you may not have a chance to use a range finder and the flatter trajectory of the 22/250 at longer range gives a wider range of "hold on the brown".
I've made quite a few hits at 1/4 mile(440 yards) with a 22/250 but don't even try if I'm using a .223. If the distance is off by just a few yards, a miss is assured plus wind drift is greater with the .223.
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