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Something that you might want to consider is that the .44/.45 has been considered a proper whitetail deer caliber since flintlocks. I'd hesitate to guess how many whitetail deer have been dropped since the late 1600s with a ~130 grain round ball pushed to black powder velocities. It's true that the new bullets give better performance, opening at velocity to match the design of the bullet, but it's also true that if you shoot a .44 caliber hole all the way through a deer you'll likely find a dead deer at the end of your walk.
Certainly, use a Deep Curl or similar design if you feel better about it, but standard lead projectiles have been bring home venison for several centuries.
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