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I know for a fact that a .22 mag. with a Sheffield scope will dust a 'Yote out to 300yds. without a problem, and with minimal pelt damage.
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Anthony, while I have no doubt you have killed 'yotes out to 300 yard with a 22 mag, it is not in my mind an ideal caliber. Inside 100 yards with a head shot; sure, but that is as far as I'd go.
This fellow anticipates taking a rare 300-500 yard shot. If I'm expecting that, I'd take a look at the 220 swift or .243 wssm (for the extra weight to buck the wind.) I'd buy a pretty high magnification scope 4-16X40 or higher that is reliably repeatable, because I'd anticipate adjusting out past 350 (or Kentucky windage and holdover after lots of experience). A rangefinder is a must beyond 400 unless you have a way to flag the target area. Learn the ballistic table if these shots are really anticipated.