There's a local guy who lost his left hand/forearm to just below his elbow. He functions quite well and uses a Ruger single action revolver but is very slow at reloading. For loading/unloading he just holds the handgun by squeezing the barrel between his stub and ribcage. Changing mags on a semiauto would seem to be fairly simple.
When I required hand surgery and was in a cast from elboe to fingertips for 8 weeks, I used my normal carry gun when my left hand was in a cast. While my right hand was in a cast, I used a single action 9mm lefty and held it between cast and body for reloads. I had to use the single action since my left hand was not strong enough to handle the heavier DA trigger pull of the Ruger P95.
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