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Are you talking lead or jacketed bullets. I am no expert, but what I have learned is that to find out for sure you must slug your barrel. Push a soft lead slug through it and measure diameter. Most guns will shoot them all. If you have a Ruger, chances are it is .452. If you use .454 it will seal better for less gas cutting but more pressure, if you use .451 it will rattle down the barrel with less acurracy as the gas slips by the the bullet. That is for lead. Jacketed, I am not so familiar, but I think that Jacketed bullets are going to be used with heavy loads anyway, so I would probably use smaller diameter so that you don't get excessive pressure. Maybe an expert can chime in. I am rather new to this, but I am reloading 45 Colt with lead.
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