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A Duplex load is a two powder load. I didn’t know Keith used them but when the 454 was being developed they tried Duplex loads. The theory is to get the bullet moving with a slow powder, then fill out the pressure curve with a fast powder to get more velocity. Apparently some of the big guns (big as in fired with a lanyard) do this successfully. When tried at the handgun level, there are problems with the powders mixing and its generally much more trouble than it is worth.
Short version, don’t try it.
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